Ontology highlight
ABSTRACT:
SUBMITTER: Lo CM
PROVIDER: S-EPMC363055 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Lo Chun-Min CM Buxton Denis B DB Chua Gregory C H GC Dembo Micah M Adelstein Robert S RS Wang Yu-Li YL
Molecular biology of the cell 20031229 3
Although myosin II is known to play an important role in cell migration, little is known about its specific functions. We have addressed the function of one of the isoforms of myosin II, myosin IIB, by analyzing the movement and mechanical characteristics of fibroblasts where this protein has been ablated by gene disruption. Myosin IIB null cells displayed multiple unstable and disorganized protrusions, although they were still able to generate a large fraction of traction forces when cultured o ...[more]