?-Synuclein and dopamine at the crossroads of Parkinson's disease.
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ABSTRACT:
SUBMITTER: Venda LL
PROVIDER: S-EPMC3631137 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
α-Synuclein and dopamine at the crossroads of Parkinson's disease.
Venda Lara Lourenço LL Cragg Stephanie J SJ Buchman Vladimir L VL Wade-Martins Richard R
Trends in neurosciences 20101018 12
α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how α-synuclein is involved. To address these questions we bring together recent findings from genome-wide association ...[more]
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