Ontology highlight
ABSTRACT:
SUBMITTER: Roitbak T
PROVIDER: S-EPMC363138 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Roitbak Tamara T Ward Christopher J CJ Harris Peter C PC Bacallao Robert R Ness Scott A SA Wandinger-Ness Angela A
Molecular biology of the cell 20040112 3
Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally caused by mutations in the gene encoding polycystin-1, a large basolateral plasma membrane protein expressed in kidney epithelial cells. Our studies reveal that, in normal kidney cells, polycystin-1 forms a complex with the adherens junction protein E-cadherin and its associated catenins, suggesting a role in ce ...[more]