Ontology highlight
ABSTRACT:
SUBMITTER: Lupfer C
PROVIDER: S-EPMC3631456 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Lupfer Christopher C Thomas Paul G PG Anand Paras K PK Vogel Peter P Milasta Sandra S Martinez Jennifer J Huang Gonghua G Green Maggie M Kundu Mondira M Chi Hongbo H Xavier Ramnik J RJ Green Douglas R DR Lamkanfi Mohamed M Dinarello Charles A CA Doherty Peter C PC Kanneganti Thirumala-Devi TD
Nature immunology 20130324 5
NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that Nod2(-/-) and Ripk2(-/-) mice are hypersusceptible to infection with influenza A virus. Ripk2(-/-) cells exhibited defective autophagy of mitochondria (mitophagy), leading to enhanced mitochondrial production of superoxide and accumulation of damaged mitochondria, which result ...[more]