Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise.
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ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC3631591 | biostudies-literature | 2012 Nov-Dec
REPOSITORIES: biostudies-literature
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Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise.
Li Mengyao M Verdijk Lex B LB Sakamoto Kei K Ely Brian B van Loon Luc J C LJ Musi Nicolas N
Mechanisms of ageing and development 20120919 11-12
AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. ...[more]
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