Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.
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ABSTRACT:
SUBMITTER: Joyner JC
PROVIDER: S-EPMC3632407 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.
Joyner Jeff C JC Hodnick W F WF Cowan Ada S AS Tamuly Deepika D Boyd Rachel R Cowan J A JA
Chemical communications (Cambridge, England) 20130205 21
Metallopeptides containing both the complex Cu(2+)-glycyl-glycyl-histidine (Cu-GGH) and the sequence WRWYCR were shown to possess antimicrobial activity against a variety of pathogenic bacteria, as well as bind to and cleave a variety of nucleic acids, suggesting potential mechanisms for antimicrobial activity that involve binding and/or irreversible cleavage of bacterial nucleic acids. ...[more]
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