Ontology highlight
ABSTRACT:
SUBMITTER: Emde A
PROVIDER: S-EPMC3632784 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Emde A A Pradeep C-R CR Ferraro D A DA Ben-Chetrit N N Sela M M Ribba B B Kam Z Z Yarden Y Y
Oncogene 20101206 14
Monoclonal antibodies (mAbs) to HER2 are currently used to treat breast cancer, but low clinical efficacy, along with primary and acquired resistance to therapy, commonly limit clinical applications. We previously reported that combinations of antibodies directed at non-overlapping epitopes of HER2 are endowed with enhanced antitumor effects, probably due to accelerated receptor degradation. Here, we extend these observations to three-dimensional mammary cell models, and compare the effects of s ...[more]