Ontology highlight
ABSTRACT:
SUBMITTER: Ramon-Garcia S
PROVIDER: S-EPMC3632949 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Ramón-García Santiago S Mikut Ralf R Ng Carol C Ruden Serge S Volkmer Rudolf R Reischl Markus M Hilpert Kai K Thompson Charles J CJ
Antimicrobial agents and chemotherapy 20130311 5
The lack of effective therapies for treating tuberculosis (TB) is a global health problem. While Mycobacterium tuberculosis is notoriously resistant to most available antibiotics, we identified synthetic short cationic antimicrobial peptides that were active at low micromolar concentrations (less than 10 μM). These small peptides (averaging 10 amino acids) had remarkably broad spectra of antimicrobial activities against both bacterial and fungal pathogens and an indication of low cytotoxicity. I ...[more]