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The African coelacanth genome provides insights into tetrapod evolution.


ABSTRACT: The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.

SUBMITTER: Amemiya CT 

PROVIDER: S-EPMC3633110 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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The African coelacanth genome provides insights into tetrapod evolution.

Amemiya Chris T CT   Alföldi Jessica J   Lee Alison P AP   Fan Shaohua S   Philippe Hervé H   Maccallum Iain I   Braasch Ingo I   Manousaki Tereza T   Schneider Igor I   Rohner Nicolas N   Organ Chris C   Chalopin Domitille D   Smith Jeramiah J JJ   Robinson Mark M   Dorrington Rosemary A RA   Gerdol Marco M   Aken Bronwen B   Biscotti Maria Assunta MA   Barucca Marco M   Baurain Denis D   Berlin Aaron M AM   Blatch Gregory L GL   Buonocore Francesco F   Burmester Thorsten T   Campbell Michael S MS   Canapa Adriana A   Cannon John P JP   Christoffels Alan A   De Moro Gianluca G   Edkins Adrienne L AL   Fan Lin L   Fausto Anna Maria AM   Feiner Nathalie N   Forconi Mariko M   Gamieldien Junaid J   Gnerre Sante S   Gnirke Andreas A   Goldstone Jared V JV   Haerty Wilfried W   Hahn Mark E ME   Hesse Uljana U   Hoffmann Steve S   Johnson Jeremy J   Karchner Sibel I SI   Kuraku Shigehiro S   Lara Marcia M   Levin Joshua Z JZ   Litman Gary W GW   Mauceli Evan E   Miyake Tsutomu T   Mueller M Gail MG   Nelson David R DR   Nitsche Anne A   Olmo Ettore E   Ota Tatsuya T   Pallavicini Alberto A   Panji Sumir S   Picone Barbara B   Ponting Chris P CP   Prohaska Sonja J SJ   Przybylski Dariusz D   Saha Nil Ratan NR   Ravi Vydianathan V   Ribeiro Filipe J FJ   Sauka-Spengler Tatjana T   Scapigliati Giuseppe G   Searle Stephen M J SM   Sharpe Ted T   Simakov Oleg O   Stadler Peter F PF   Stegeman John J JJ   Sumiyama Kenta K   Tabbaa Diana D   Tafer Hakim H   Turner-Maier Jason J   van Heusden Peter P   White Simon S   Williams Louise L   Yandell Mark M   Brinkmann Henner H   Volff Jean-Nicolas JN   Tabin Clifford J CJ   Shubin Neil N   Schartl Manfred M   Jaffe David B DB   Postlethwait John H JH   Venkatesh Byrappa B   Di Palma Federica F   Lander Eric S ES   Meyer Axel A   Lindblad-Toh Kerstin K  

Nature 20130401 7445


The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lung  ...[more]

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