Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations.
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ABSTRACT:
SUBMITTER: Hyde HC
PROVIDER: S-EPMC3633233 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations.
Hyde H Clark HC Sandtner Walter W Vargas Ernesto E Dagcan Alper T AT Robertson Janice L JL Roux Benoit B Correa Ana M AM Bezanilla Francisco F
Structure (London, England : 1993) 20121001 10
Proteins may undergo multiple conformational changes required for their function. One strategy used to estimate target-site positions in unknown structural conformations involves single-pair resonance energy transfer (RET) distance measurements. However, interpretation of inter-residue distances is difficult when applied to three-dimensional structural rearrangements, especially in homomeric systems. We developed a positioning method using inverse trilateration/triangulation to map target sites ...[more]
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