Ontology highlight
ABSTRACT:
SUBMITTER: Deelen J
PROVIDER: S-EPMC3633240 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Deelen Joris J Beekman Marian M Capri Miriam M Franceschi Claudio C Slagboom P Eline PE
BioEssays : news and reviews in molecular, cellular and developmental biology 20130219 4
Human lifespan variation is mainly determined by environmental factors, whereas the genetic contribution is 25-30% and expected to be polygenic. Two complementary fields go hand in hand in order to unravel the mechanisms of biological aging: genomic and biomarker research. Explorative and candidate gene studies of the human genome by genetic, transcriptomic, and epigenomic approaches have resulted in the identification of a limited number of interesting positive linkage regions, genes, and pathw ...[more]