Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC3633418 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Liu Lin L De Subhajyoti S Michor Franziska F
Nature communications 20130101
Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and cancer genomes. Using data on five fully sequenced cancer types and two personal genomes, we determined that the frequency of intergenic single-nucleotide substitution is significantly ...[more]