Ontology highlight
ABSTRACT:
SUBMITTER: Oh H
PROVIDER: S-EPMC3633442 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Oh Hyangyee H Slattery Matthew M Ma Lijia L Crofts Alex A White Kevin P KP Mann Richard S RS Irvine Kenneth D KD
Cell reports 20130208 2
The Hippo pathway regulates growth through the transcriptional coactivator Yorkie, but how Yorkie promotes transcription remains poorly understood. We address this by characterizing Yorkie's association with chromatin and by identifying nuclear partners that effect transcriptional activation. Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Mediator complex as Yorkie-associated nuclear protein complexes. All three are required for Yorkie's trans ...[more]