Subgroup specific incremental value of new markers for risk prediction.

ABSTRACT: In many clinical applications, understanding when measurement of new markers is necessary to provide added accuracy to existing prediction tools could lead to more cost effective disease management. Many statistical tools for evaluating the incremental value (IncV) of the novel markers over the routine clinical risk factors have been developed in recent years. However, most existing literature focuses primarily on global assessment. Since the IncVs of new markers often vary across subgroups, it would be of great interest to identify subgroups for which the new markers are most/least useful in improving risk prediction. In this paper we provide novel statistical procedures for systematically identifying potential traditional-marker based subgroups in whom it might be beneficial to apply a n

SUBMITTER: Zhou QM 

PROVIDER: S-EPMC3633735 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature