Dataset Information

Population-based 5-year follow-up study in Taiwan of dementia and risk of stroke.

ABSTRACT:

Background

This study estimates the risk of stroke within 5 years of newly diagnosed dementia among elderly persons aged 65 and above. We examined the relationship between antipsychotic usage and development of stroke in patients with dementia.

Methods

We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 2243 patients with dementia aged ?65 years who had at least one inpatient service claim or at least 2 ambulatory care claims, whereas the comparison cohort consisted of 6714 randomly selected subjects (3 for every dementia patient) and were matched with the study group according to sex, age, and index year. We further classified dementia patients into 2 groups based on their history of antipsychotic usage. A total of 1450 patients were classified into the antipsychotic usage group and the remaining 793 patients were classified into the non-antipsychotic usage group. Cox proportional-hazards regressions were performed to compute the 5-year stroke-free survival rates after adjusting for potentially confounding factors.

Results

The dementia patients have a 2-fold greater risk of developing stroke within 5 years of diagnosis compared to non-dementia age- and sex-matched subjects, after adjusting for other risk factors (95% confidence interval (CI)?=?2.58-3.08; P<.001). Antipsychotic usage among patients with dementia increases risk of stroke 1.17-fold compared to patients without antipsychotic treatment (95% CI?=?1.01-1.40; P<.05).

Conclusions

Dementia may be an independent risk factor for stroke, and the use of antipsychotics may further increase the risk of stroke in dementia patients.

SUBMITTER: Liu ME

PROVIDER: S-EPMC3634021 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Population-based 5-year follow-up study in Taiwan of dementia and risk of stroke.

Liu Mu-En ME Tsai Shih-Jen SJ Chang Wei-Chiao WC Hsu Chun-Hung CH Lu Ti T Hung Kuo-Sheng KS Chiu Wen-Ta WT Chang Wei-Pin WP

PloS one 20130423 4

<h4>Background</h4>This study estimates the risk of stroke within 5 years of newly diagnosed dementia among elderly persons aged 65 and above. We examined the relationship between antipsychotic usage and development of stroke in patients with dementia.<h4>Methods</h4>We conducted a nationwide 5-year population-based study using data retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 2243 patients with dementia aged ≥65 years who had at ...[more]

PMID: 23626726

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Dataset Information

Population-based 5-year follow-up study in Taiwan of dementia and risk of stroke.

Background

Methods

Results

Conclusions

Publications

Population-based 5-year follow-up study in Taiwan of dementia and risk of stroke.

Similar Datasets

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