9G DNAChip Technology: Self-Assembled Monolayer (SAM) of ssDNA for Ultra-Sensitive Detection of Biomarkers.
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ABSTRACT:
SUBMITTER: Nimse SB
PROVIDER: S-EPMC3634481 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
9G DNAChip Technology: Self-Assembled Monolayer (SAM) of ssDNA for Ultra-Sensitive Detection of Biomarkers.
Nimse Satish Balasaheb SB Song Keum-Soo KS Kim Junghoon J Sayyed Danishmalik Rafiq DR Kim Taisun T
International journal of molecular sciences 20130312 3
A 9G DNAChip obtained by allowing the formation of a self-assembled monolayer (SAM) of oligonucleotides appended with nine consecutive guanines on the chip surface has been applied in the detection of biomarkers. Using a 9G DNAChip, biomarker in the concentration range of 4 pg/mL to 40 fg/mL can be easily differentiated in the buffer matrix. Moreover, it is the first time that a biomarker with a concentration of 40 fg/mL has been detected in a mixture of proteins without use of any signal amplif ...[more]
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