GSTT1 null genotype contributes to lung cancer risk in asian populations: a meta-analysis of 23 studies.

ABSTRACT:

Background

Genetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results.

Methodology/principal findings

We performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR?=?1.28, 95% CI?=?1.10, 1.49; Pheterogeneity<0.001 and I(2)?=?62.0%). Sub-group analysis revealed there was a statistically increased lung cancer risk in ever-smokers who carried the GSTT1 null genotype (OR?=?1.94, 95% CI?=?1.27, 2.96; P heterogeneity?=?0.02 and I(2)?=?58.1%). It was also indicated that GSTT1 null genotype could increase lung cancer risk among population-based studies (OR?=?1.25, 95% CI?=?1.04, 1.50; Pheterogeneity?=?0.003 and I(2)?=?56.8%). The positive association was also found in studies of sample size (?500 participants) (OR?=?1.34, 95% CI?=?1.10, 1.62; Pheterogeneity<0.001 and I(2)?=?65.4%).

Conclusions

These meta-analysis results suggest that GSTT1 null genotype is associated with a significantly increased risk of lung cancer in Asian population.

SUBMITTER: Yang X 

PROVIDER: S-EPMC3634775 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature