Ontology highlight
ABSTRACT:
SUBMITTER: Klipcan L
PROVIDER: S-EPMC3634914 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Klipcan Liron L Safro Mark M Schimmel Paul P
Trends in biochemical sciences 20121219 5
Ancient mechanisms for nucleotide base recognition in the RNA world are candidates for mimicking by early proteins like tRNA synthetases. In the core of the tRNA, conserved G22 interacts with two internal bases in a complex further stabilized by stacking interactions. This particular tRNA format for G recognition is shown here to be adapted by nine different and even nonhomologous anticodon binding domains (ABDs) of tRNA synthetases, in which amino acid side chains mimic all of the tRNA G22 base ...[more]