Ontology highlight
ABSTRACT:
SUBMITTER: Jansen C
PROVIDER: S-EPMC3635145 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Jansen Chimed C Wang Huanchen H Kooistra Albert J AJ de Graaf Chris C Orrling Kristina M KM Tenor Hermann H Seebeck Thomas T Bailey David D de Esch Iwan J P IJ Ke Hengming H Leurs Rob R
Journal of medicinal chemistry 20130301 5
Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African trypanosomiasis by both genetic and pharmacological means. In this study we report the crystal structure of the catalytic domain of the unliganded TbrPDEB1 and its use for the in silico screening for new TbrPDEB1 inhibitors with novel scaffolds. The TbrPDEB1 crystal structure shows the characteristic folds of human PDE enzymes but also contai ...[more]