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Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial.


ABSTRACT: Several randomized clinical trials (RCTs) indicate that flavanol-rich chocolate has beneficial effects on flow-mediated dilation (FMD) and blood pressure (BP). However, no RCTs have evaluated these outcomes in pregnant women. The objective of this 2-group, parallel, double-blind RCT was to examine the effects of flavanol-rich chocolate on FMD and BP in pregnant women with normal BP.Forty-four healthy, pregnant women were randomized to the high-flavanol (n?=?23) or low-flavanol (n?=?21) chocolate consumption for 12 weeks. At randomization (0, 60, 120 and 180 min after a single 40-g dose of chocolate), 6 and 12 weeks after daily 20-g chocolate intake, we evaluated plasma concentrations of flavanols and theobromine, as well as the FMD and BP.Plasma epicatechin was significantly increased (p?

SUBMITTER: Mogollon JA 

PROVIDER: S-EPMC3635935 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Blood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trial.

Mogollon Jaime Andres JA   Bujold Emmanuel E   Lemieux Simone S   Bourdages Mélodie M   Blanchet Claudine C   Bazinet Laurent L   Couillard Charles C   Noël Martin M   Dodin Sylvie S  

Nutrition journal 20130408


<h4>Background</h4>Several randomized clinical trials (RCTs) indicate that flavanol-rich chocolate has beneficial effects on flow-mediated dilation (FMD) and blood pressure (BP). However, no RCTs have evaluated these outcomes in pregnant women. The objective of this 2-group, parallel, double-blind RCT was to examine the effects of flavanol-rich chocolate on FMD and BP in pregnant women with normal BP.<h4>Methods</h4>Forty-four healthy, pregnant women were randomized to the high-flavanol (n = 23)  ...[more]

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