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Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from giant panda and raccoon dogs in China.


ABSTRACT: BACKGROUND: Canine distemper virus (CDV) infects a variety of carnivores, including wild and domestic Canidae. In this study, we sequenced and phylogenetic analyses of the hemagglutinin (H) genes from eight canine distemper virus (CDV) isolates obtained from seven raccoon dogs (Nyctereutes procyonoides) and a giant panda (Ailuropoda melanoleuca) in China. RESULTS: Phylogenetic analysis of the partial hemagglutinin gene sequences showed close clustering for geographic lineages, clearly distinct from vaccine strains and other wild-type foreign CDV strains, all the CDV strains were characterized as Asia-1 genotype and were highly similar to each other (91.5-99.8% nt and 94.4-99.8% aa). The giant panda and raccoon dogs all were 549Y on the HA protein in this study, irrespective of the host species. CONCLUSIONS: These findings enhance our knowledge of the genetic characteristics of Chinese CDV isolates, and may facilitate the development of effective strategies for monitoring and controlling CDV for wild canids and non-canids in China.

SUBMITTER: Guo L 

PROVIDER: S-EPMC3636003 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from giant panda and raccoon dogs in China.

Guo Ling L   Yang Shao-lin SL   Wang Cheng-dong CD   Hou Rong R   Chen Shi-jie SJ   Yang Xiao-nong XN   Liu Jie J   Pan Hai-bo HB   Hao Zhong-xiang ZX   Zhang Man-li ML   Cao San-jie SJ   Yan Qi-gui QG  

Virology journal 20130408


<h4>Background</h4>Canine distemper virus (CDV) infects a variety of carnivores, including wild and domestic Canidae. In this study, we sequenced and phylogenetic analyses of the hemagglutinin (H) genes from eight canine distemper virus (CDV) isolates obtained from seven raccoon dogs (Nyctereutes procyonoides) and a giant panda (Ailuropoda melanoleuca) in China.<h4>Results</h4>Phylogenetic analysis of the partial hemagglutinin gene sequences showed close clustering for geographic lineages, clear  ...[more]

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