Ontology highlight
ABSTRACT:
SUBMITTER: Tsuchiya K
PROVIDER: S-EPMC3636600 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Tsuchiya Kyoichiro K Accili Domenico D
Diabetes 20130124 5
Insulin signaling in vascular endothelial cells (ECs) is critical to maintain endothelial function but also to mediate insulin action on peripheral glucose disposal. However, gene knockout studies have reached disparate conclusions. Thus, insulin receptor inactivation in ECs does not impair insulin action, whereas inactivation of Irs2 does. Previously, we have shown that endothelial ablation of the three Foxo genes protects mice from atherosclerosis. Interestingly, here we show that mice lacking ...[more]