Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

ABSTRACT:

Background and aims

Drug-induced liver injury (DILI) is a serious adverse drug event that is suspected to have a heritable component. We carried out a genome-wide association study of 783 individuals of European ancestry who experienced DILI due to more than 200 implicated drugs.

Methods

DILI patients from the US-based Drug-Induced Liver Injury Network (n=401) and three international registries (n=382) were genotyped with the Illumina 1Mduo BeadChip and compared with population controls (n=3001). Potential associations were tested in 307 independent Drug-Induced Liver Injury Network cases.

Results

After accounting for known major histocompatibility complex risk alleles for flucloxacillin-DILI and amoxicillin/clavulanate-DILI, there were no genome-wide significant asso

SUBMITTER: Urban TJ 

PROVIDER: S-EPMC3636716 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature