Ontology highlight
ABSTRACT:
SUBMITTER: Fu HL
PROVIDER: S-EPMC3636896 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Fu Hsueh-Liang HL Sohail Anjum A Valiathan Rajeshwari R RR Wasinski Benjamin D BD Kumarasiri Malika M Mahasenan Kiran V KV Bernardo M Margarida MM Tokmina-Roszyk Dorota D Fields Gregg B GB Mobashery Shahriar S Fridman Rafael R
The Journal of biological chemistry 20130321 17
The discoidin domain receptors (DDRs) are receptor tyrosine kinases that upon binding to collagens undergo receptor phosphorylation, which in turn activates signal transduction pathways that regulate cell-collagen interactions. We report here that collagen-dependent DDR1 activation is partly regulated by the proteolytic activity of the membrane-anchored collagenases, MT1-, MT2-, and MT3-matrix metalloproteinase (MMP). These collagenases cleave DDR1 and attenuate collagen I- and IV-induced recept ...[more]