Ontology highlight
ABSTRACT:
SUBMITTER: Shonesy BC
PROVIDER: S-EPMC3636998 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Nature neuroscience 20130317 4
The endocannabinoid 2-arachidonoylglycerol (2-AG) mediates activity-dependent depression of excitatory neurotransmission at central synapses, but the molecular regulation of 2-AG synthesis is not well understood. Here we identify a functional interaction between the 2-AG synthetic enzyme diacylglycerol lipase-α (DGLα) and calcium/calmodulin dependent protein kinase II (CaMKII). Activated CaMKII interacted with the C-terminal domain of DGLα, phosphorylated two serine residues and inhibited DGLα a ...[more]