Ontology highlight
ABSTRACT:
SUBMITTER: Ackerman ME
PROVIDER: S-EPMC3637034 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Ackerman Margaret E ME Crispin Max M Yu Xiaojie X Baruah Kavitha K Boesch Austin W AW Harvey David J DJ Dugast Anne-Sophie AS Heizen Erin L EL Ercan Altan A Choi Ickwon I Streeck Hendrik H Nigrovic Peter A PA Bailey-Kellogg Chris C Scanlan Chris C Alter Galit G
The Journal of clinical investigation 20130408 5
While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible to induce antibodies with enhanced Fc effector activity and improved antiviral control via vaccination. However, the specific features of naturally induced HIV-specific antibodies that allow for the potent recruitment of antiviral activity and the means by which these functions are regulated are poorly d ...[more]