Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3637714 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Li Yue Y Wang Jimin J Kanai Ryuta R Modis Yorgo Y
Proceedings of the National Academy of Sciences of the United States of America 20130408 17
Pestiviruses, including bovine viral diarrhea virus, are important animal pathogens and are closely related to hepatitis C virus, which remains a major global health threat. They have an outer lipid envelope bearing two glycoproteins, E1 and E2, required for cell entry. They deliver their genome into the host cell cytoplasm by fusion of their envelope with a cellular membrane. The crystal structure of bovine viral diarrhea virus E2 reveals a unique protein architecture consisting of two Ig-like ...[more]