Ontology highlight
ABSTRACT:
SUBMITTER: Yosef N
PROVIDER: S-EPMC3637864 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Yosef Nir N Shalek Alex K AK Gaublomme Jellert T JT Jin Hulin H Lee Youjin Y Awasthi Amit A Wu Chuan C Karwacz Katarzyna K Xiao Sheng S Jorgolli Marsela M Gennert David D Satija Rahul R Shakya Arvind A Lu Diana Y DY Trombetta John J JJ Pillai Meenu R MR Ratcliffe Peter J PJ Coleman Mathew L ML Bix Mark M Tantin Dean D Park Hongkun H Kuchroo Vijay K VK Regev Aviv A
Nature 20130306 7446
Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on perturbation-based approaches that cannot be readily applied to primary T cells. Here we combine transcriptional profiling at high temporal resolution, novel computational algorithms, and innovative nanowire-based perturbation tools to systematically de ...[more]