Ontology highlight
ABSTRACT:
SUBMITTER: Lepagnol-Bestel AM
PROVIDER: S-EPMC3637956 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Lepagnol-Bestel A M AM Kvajo M M Karayiorgou M M Simonneau M M Gogos J A JA
Molecular and cellular neurosciences 20130206
A balanced chromosomal translocation segregating with schizophrenia and affective disorders in a large Scottish family disrupting DISC1 implicated this gene as a susceptibility gene for major mental illness. Here we study neurons derived from a genetically engineered mouse strain with a truncating lesion disrupting the endogenous Disc1 ortholog. We provide a detailed account of the consequences of this mutation on axonal and dendritic morphogenesis as well as dendritic spine development in cultu ...[more]