TFEB links autophagy to lysosomal biogenesis.
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ABSTRACT:
SUBMITTER: Settembre C
PROVIDER: S-EPMC3638014 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
TFEB links autophagy to lysosomal biogenesis.
Settembre Carmine C Di Malta Chiara C Polito Vinicia Assunta VA Garcia Arencibia Moises M Vetrini Francesco F Erdin Serkan S Erdin Serpil Uckac SU Huynh Tuong T Medina Diego D Colella Pasqualina P Sardiello Marco M Rubinsztein David C DC Ballabio Andrea A
Science (New York, N.Y.) 20110526 6036
Autophagy is a cellular catabolic process that relies on the cooperation of autophagosomes and lysosomes. During starvation, the cell expands both compartments to enhance degradation processes. We found that starvation activates a transcriptional program that controls major steps of the autophagic pathway, including autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. The transcription factor EB (TFEB), a master gene for lysosomal biogenesis, coordinated this progra ...[more]
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