Unknown

Dataset Information

0

A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

ABSTRACT: In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling activation, and up-regulation of IGF-binding protein-3 (IGFBP-3) expression may be associated with deguelin-mediated antitumor effects. Our findings suggest a potential therapeutic use for deguelin in patients with triple-negative breast cancer and for those with breast cancers who are sensitive to endocrine- and HER2-targeted therapies.

SUBMITTER: Suh YA 

PROVIDER: S-EPMC3638119 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.

Suh Young-Ah YA   Kim Jai-Hyun JH   Sung Myung A MA   Boo Hye-Jin HJ   Yun Hye Jeong HJ   Lee Sun-Hye SH   Lee Hyo-Jong HJ   Min Hye-Young HY   Suh Young-Ger YG   Kim Kyu-Won KW   Lee Ho-Young HY  

Cancer letters 20130121 1

In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling acti  ...[more]

Similar Datasets

Unknown Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies.
| S-EPMC5610669 | biostudies-literature
Unknown Insulin-like growth factor (IGF) binding protein-5 blocks skeletal muscle differentiation by inhibiting IGF actions.
| S-EPMC2194633 | biostudies-literature
Unknown Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury.
| S-EPMC1698774 | biostudies-literature
Unknown The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.
| S-EPMC2782004 | biostudies-literature
Unknown Up-regulation of Insulin-like Growth Factor Binding Protein-3 Is Associated with Brain Metastasis in Lung Adenocarcinoma.
| S-EPMC6530643 | biostudies-literature
Unknown Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.
| S-EPMC3227035 | biostudies-literature
Unknown Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway.
| S-EPMC5787453 | biostudies-literature
Unknown Genetic and dietary determinants of insulin-like growth factor (IGF)-1 and IGF binding protein (BP)-3 levels among Chinese women.
| S-EPMC4186782 | biostudies-literature
Unknown Targeting the insulin-like growth factor pathway in hepatocellular carcinoma.
| S-EPMC4209417 | biostudies-literature
Unknown Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.
| S-EPMC2989404 | biostudies-literature