Ontology highlight
ABSTRACT:
SUBMITTER: Suh YA
PROVIDER: S-EPMC3638119 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cancer letters 20130121 1
In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling acti ...[more]