Ontology highlight
ABSTRACT:
SUBMITTER: Alfaro LA
PROVIDER: S-EPMC3638793 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Alfaro Leslie Ann So LA Dick Sarah A SA Siegel Ashley L AL Anonuevo Adam S AS McNagny Kelly M KM Megeney Lynn A LA Cornelison D D W DD Rossi Fabio M V FM
Stem cells (Dayton, Ohio) 20111201 12
Expression of the cell surface sialomucin CD34 is common to many adult stem cell types, including muscle satellite cells. However, no clear stem cell or regeneration-related phenotype has ever been reported in mice lacking CD34, and its function on these cells remains poorly understood. Here, we assess the functional role of CD34 on satellite cell-mediated muscle regeneration. We show that Cd34(-/-) mice, which have no obvious developmental phenotype, display a defect in muscle regeneration when ...[more]