Ontology highlight
ABSTRACT:
SUBMITTER: Heo JM
PROVIDER: S-EPMC3639040 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Heo Jin-Mi JM Nielson Jason R JR Dephoure Noah N Gygi Steven P SP Rutter Jared J
Molecular biology of the cell 20130306 9
Mitochondrial dysfunction is associated with the development of many age-related human diseases. Therefore recognizing and correcting the early signs of malfunctioning mitochondria is of critical importance for cellular welfare and survival. We previously demonstrated that VCP/Cdc48-associated mitochondrial stress responsive 1 (Vms1) is a component of a mitochondrial surveillance system that mediates the stress-responsive degradation of mitochondrial proteins by the proteasome. Here we propose n ...[more]