Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa T
PROVIDER: S-EPMC3639050 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Ishikawa Tokiro T Okada Tetsuya T Ishikawa-Fujiwara Tomoko T Todo Takeshi T Kamei Yasuhiro Y Shigenobu Shuji S Tanaka Minoru M Saito Taro L TL Yoshimura Jun J Morishita Shinichi S Toyoda Atsushi A Sakaki Yoshiyuki Y Taniguchi Yoshihito Y Takeda Shunichi S Mori Kazutoshi K
Molecular biology of the cell 20130227 9
ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins. ATF6α- and ATF6β single-knockout mice develop normally, but ATF6α/β double knockout causes embryonic lethality, the reason for which is unknown. Here we show in medaka fish that ATF6α is primarily responsible for transcriptional induction of the major ER chaperone BiP and that ATF6α/β double knock ...[more]