Ontology highlight
ABSTRACT:
SUBMITTER: Neisch AL
PROVIDER: S-EPMC3639053 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Neisch Amanda L AL Formstecher Etienne E Fehon Richard G RG
Molecular biology of the cell 20130306 9
RhoA, a small GTPase, regulates epithelial integrity and morphogenesis by controlling filamentous actin assembly and actomyosin contractility. Another important cytoskeletal regulator, Moesin (Moe), an ezrin, radixin, and moesin (ERM) protein, has the ability to bind to and organize cortical F-actin, as well as the ability to regulate RhoA activity. ERM proteins have previously been shown to interact with both RhoGEF (guanine nucleotide exchange factors) and RhoGAP (GTPase activating proteins), ...[more]