Ontology highlight
ABSTRACT:
SUBMITTER: Muralidharan V
PROVIDER: S-EPMC3639100 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Muralidharan Vasant V Oksman Anna A Pal Priya P Lindquist Susan S Goldberg Daniel E DE
Nature communications 20120101
One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at febrile temperatures, as did a yeast Asn/Gln-rich protein (Sup35). Co-expression of the cytoplasmic P. falciparum heat shock protein 110 (PfHsp110c) prevented aggregation. Human or yea ...[more]