Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis.

ABSTRACT:

Background

Because of the role of inflammation in preterm birth (PTB), polymorphisms in and near the interleukin-6 gene (IL6) have been association study targets. Several previous studies have assessed the association between PTB and a single nucleotide polymorphism (SNP), rs1800795, located in the IL6 gene promoter region. Their results have been inconsistent and SNP frequencies have varied strikingly among different populations. We therefore conducted a meta-analysis with subgroup analysis by population strata to: (1) reduce the confounding effect of population structure, (2) increase sample size and statistical power, and (3) elucidate the association between rs1800975 and PTB.

Results

We reviewed all published papers for PTB phenotype and SNP rs1800795 genotype. Maternal

SUBMITTER: Wu W 

PROVIDER: S-EPMC3639799 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature