Ontology highlight
ABSTRACT:
SUBMITTER: Sheppard HM
PROVIDER: S-EPMC3640030 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sheppard Hilary M HM Ussher James E JE Verdon Daniel D Chen Jennifer J Taylor John A JA Dunbar P Rod PR
PloS one 20130430 4
The study of melanocyte biology is important to understand their role in health and disease. However, current methods of gene transfer into melanocytes are limited by safety or efficacy. Recombinant adeno-associated virus (rAAV) has been extensively investigated as a gene therapy vector, is safe and is associated with persistent transgene expression without genome integration. There are twelve serotypes and many capsid variants of rAAV. However, a comparative study to determine which rAAV is mos ...[more]