Ontology highlight
ABSTRACT:
SUBMITTER: Rask-Madsen C
PROVIDER: S-EPMC3640325 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Rask-Madsen Christian C Buonomo Erica E Li Qian Q Park Kyoungmin K Clermont Allen C AC Yerokun Oluwatobi O Rekhter Mark M King George L GL
Arteriosclerosis, thrombosis, and vascular biology 20120315 5
<h4>Objective</h4>To determine the contribution of hyperinsulinemia to atherosclerosis development.<h4>Methods and results</h4>Apolipoprotein E (Apoe) null mice that had knockout of a single allele of the insulin receptor (Insr) gene were compared with littermate Apoe null mice with intact insulin receptors. Plasma insulin levels in Insr haploinsufficient/Apoe null mice were 50% higher in the fasting state and up to 69% higher during a glucose tolerance test, but glucose tolerance was not differ ...[more]