Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice.

ABSTRACT:

Objective

To determine the contribution of hyperinsulinemia to atherosclerosis development.

Methods and results

Apolipoprotein E (Apoe) null mice that had knockout of a single allele of the insulin receptor (Insr) gene were compared with littermate Apoe null mice with intact insulin receptors. Plasma insulin levels in Insr haploinsufficient/Apoe null mice were 50% higher in the fasting state and up to 69% higher during a glucose tolerance test, but glucose tolerance was not different in the 2 groups. C-peptide levels, insulin sensitivity, and postreceptor insulin signaling in muscle, liver, fat, and aorta were not different between groups, whereas disappearance in plasma of an injected insulin analog was delayed in Insr haploinsufficient/Apoe null mice, indicating that impai

SUBMITTER: Rask-Madsen C 

PROVIDER: S-EPMC3640325 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature