Ontology highlight
ABSTRACT:
SUBMITTER: Loiselle AE
PROVIDER: S-EPMC3640531 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Loiselle Alayna E AE Paul Emmanuel M EM Lewis Gregory S GS Donahue Henry J HJ
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20120620 1
Connexin43 (Cx43) plays an important role in osteoblastic differentiation in vitro, and bone formation in vivo. Mice with osteoblast/osteocyte-specific loss of Cx43 display decreased gap junctional intercellular communication (GJIC), bone density, and cortical thickness. To determine the role of Cx43 in fracture healing, a closed femur fracture was induced in Osteocalcin-Cre+; Cx43(flox/flox) (Cx43cKO) and Cre-; Cx43(flox/flox) (WT) mice. We tested the hypothesis that loss of Cx43 results in dec ...[more]