Ontology highlight
ABSTRACT:
SUBMITTER: Beckstead MJ
PROVIDER: S-EPMC3640552 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090311 8
Dopamine neurons in the ventral midbrain contribute to learning and memory of natural and drug-related rewards. Corticotropin-releasing factor (CRF), a stress-related peptide, is thought to be involved in aspects of relapse following drug withdrawal, but the cellular actions are poorly understood. This study investigates the action of CRF on G-protein-linked inhibitory postsynaptic currents (IPSCs) mediated by GIRK (Kir3) channels in dopamine neurons. CRF enhanced the amplitude and slowed the ki ...[more]