Genome-wide association study of severity in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system with a strong genetic component. Several lines of evidence support a strong role for genetic factors influencing both disease susceptibility and clinical outcome in MS. Identification of genetic variants that distinguish particular disease subgroups and/or predict a severe clinical outcome is critical to further our understanding of disease mechanisms and guide development of effective therapeutic approaches. We studied 1470 MS cases and performed a genome-wide association study of more than 2.5 million single-nucleotide polymorphisms to identify loci influencing disease severity, measured using the MS severity score (MSSS), a measure of clinical disability. Of note, no single result achieved genome-wi

SUBMITTER: International Multiple Sclerosis Genetics Consortium 

PROVIDER: S-EPMC3640650 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature