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A variant in FTO shows association with melanoma risk not due to BMI.


ABSTRACT: We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

SUBMITTER: Iles MM 

PROVIDER: S-EPMC3640814 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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A variant in FTO shows association with melanoma risk not due to BMI.

Iles Mark M MM   Law Matthew H MH   Stacey Simon N SN   Han Jiali J   Fang Shenying S   Pfeiffer Ruth R   Harland Mark M   Macgregor Stuart S   Taylor John C JC   Aben Katja K KK   Akslen Lars A LA   Avril Marie-Françoise MF   Azizi Esther E   Bakker Bert B   Benediktsdottir Kristrun R KR   Bergman Wilma W   Scarrà Giovanna Bianchi GB   Brown Kevin M KM   Calista Donato D   Chaudru Valérie V   Fargnoli Maria Concetta MC   Cust Anne E AE   Demenais Florence F   de Waal Anne C AC   Dębniak Tadeusz T   Elder David E DE   Friedman Eitan E   Galan Pilar P   Ghiorzo Paola P   Gillanders Elizabeth M EM   Goldstein Alisa M AM   Gruis Nelleke A NA   Hansson Johan J   Helsing Per P   Hočevar Marko M   Höiom Veronica V   Hopper John L JL   Ingvar Christian C   Janssen Marjolein M   Jenkins Mark A MA   Kanetsky Peter A PA   Kiemeney Lambertus A LA   Lang Julie J   Lathrop G Mark GM   Leachman Sancy S   Lee Jeffrey E JE   Lubiński Jan J   Mackie Rona M RM   Mann Graham J GJ   Martin Nicholas G NG   Mayordomo Jose I JI   Molven Anders A   Mulder Suzanne S   Nagore Eduardo E   Novaković Srdjan S   Okamoto Ichiro I   Olafsson Jon H JH   Olsson Håkan H   Pehamberger Hubert H   Peris Ketty K   Grasa Maria Pilar MP   Planelles Dolores D   Puig Susana S   Puig-Butille Joan Anton JA   Randerson-Moor Juliette J   Requena Celia C   Rivoltini Licia L   Rodolfo Monica M   Santinami Mario M   Sigurgeirsson Bardur B   Snowden Helen H   Song Fengju F   Sulem Patrick P   Thorisdottir Kristin K   Tuominen Rainer R   Van Belle Patricia P   van der Stoep Nienke N   van Rossum Michelle M MM   Wei Qingyi Q   Wendt Judith J   Zelenika Diana D   Zhang Mingfeng M   Landi Maria Teresa MT   Thorleifsson Gudmar G   Bishop D Timothy DT   Amos Christopher I CI   Hayward Nicholas K NK   Stefansson Kari K   Bishop Julia A Newton JA   Barrett Jennifer H JH  

Nature genetics 20130303 4


We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10(-12), per-allele odds ratio for allele A = 1.16). In ad  ...[more]

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