Ontology highlight
ABSTRACT:
SUBMITTER: Iles MM
PROVIDER: S-EPMC3640814 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Iles Mark M MM Law Matthew H MH Stacey Simon N SN Han Jiali J Fang Shenying S Pfeiffer Ruth R Harland Mark M Macgregor Stuart S Taylor John C JC Aben Katja K KK Akslen Lars A LA Avril Marie-Françoise MF Azizi Esther E Bakker Bert B Benediktsdottir Kristrun R KR Bergman Wilma W Scarrà Giovanna Bianchi GB Brown Kevin M KM Calista Donato D Chaudru Valérie V Fargnoli Maria Concetta MC Cust Anne E AE Demenais Florence F de Waal Anne C AC Dębniak Tadeusz T Elder David E DE Friedman Eitan E Galan Pilar P Ghiorzo Paola P Gillanders Elizabeth M EM Goldstein Alisa M AM Gruis Nelleke A NA Hansson Johan J Helsing Per P Hočevar Marko M Höiom Veronica V Hopper John L JL Ingvar Christian C Janssen Marjolein M Jenkins Mark A MA Kanetsky Peter A PA Kiemeney Lambertus A LA Lang Julie J Lathrop G Mark GM Leachman Sancy S Lee Jeffrey E JE Lubiński Jan J Mackie Rona M RM Mann Graham J GJ Martin Nicholas G NG Mayordomo Jose I JI Molven Anders A Mulder Suzanne S Nagore Eduardo E Novaković Srdjan S Okamoto Ichiro I Olafsson Jon H JH Olsson Håkan H Pehamberger Hubert H Peris Ketty K Grasa Maria Pilar MP Planelles Dolores D Puig Susana S Puig-Butille Joan Anton JA Randerson-Moor Juliette J Requena Celia C Rivoltini Licia L Rodolfo Monica M Santinami Mario M Sigurgeirsson Bardur B Snowden Helen H Song Fengju F Sulem Patrick P Thorisdottir Kristin K Tuominen Rainer R Van Belle Patricia P van der Stoep Nienke N van Rossum Michelle M MM Wei Qingyi Q Wendt Judith J Zelenika Diana D Zhang Mingfeng M Landi Maria Teresa MT Thorleifsson Gudmar G Bishop D Timothy DT Amos Christopher I CI Hayward Nicholas K NK Stefansson Kari K Bishop Julia A Newton JA Barrett Jennifer H JH
Nature genetics 20130303 4
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10(-12), per-allele odds ratio for allele A = 1.16). In ad ...[more]