Ontology highlight
ABSTRACT:
SUBMITTER: Jeng HH
PROVIDER: S-EPMC3640996 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Jeng Hao-Hsuan HH Taylor Laura J LJ Bar-Sagi Dafna D
Nature communications 20120101
Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although in a given tumour type, oncogenic mutations are selectively observed in only one of the ras genes, the acquisition of the transformed phenotype has been shown to require the contribution of the normal products of the other ras genes. Here we demonstrate that oncogenic K-Ras promotes the activation of wild-type H- and N-Ras. This activation is mediated by oncogenic K-Ras-dependent allosteric stimulation of S ...[more]