Ontology highlight
ABSTRACT:
SUBMITTER: Boehlke C
PROVIDER: S-EPMC3641035 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Boehlke Christopher C Kotsis Fruzsina F Buchholz Bjoern B Powelske Christian C Eckardt Kai-Uwe KU Walz Gerd G Nitschke Roland R Kuehn E Wolfgang EW
PloS one 20130501 5
The microtubular motor Kinesin-2 and its subunit Kif3a are essential for the formation of primary cilia, an organelle implicated in a wide spectrum of developmental abnormalities. Outside cilia, Kinesin-2 mediated transport has been implicated in vesicle and N-cadherin transport, but it is unknown if and how extraciliary Kif3a affects basic cellular functions such as migration or the formation of multicellular structures. Here we show that tetracycline inducible depletion of Kif3a in MDCK cells ...[more]