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Low intensity ultrasound perturbs cytoskeleton dynamics.

ABSTRACT: Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10(-5)) at ultrasonic frequencies (10(6) Hz), but are closely analogous to those caused by relatively large strains (10(-1)) at physiological frequencies (10(0) Hz). Moreover, these changes are reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials. As such, we suggest cytoskeletal fluidization together with resulting acceleration of cytoskeletal remodeling events as a mechanism contributing to the salutary effects of low intensity therapeutic ultrasound.

SUBMITTER: Mizrahi N

PROVIDER: S-EPMC3641826 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Low intensity ultrasound perturbs cytoskeleton dynamics.

Mizrahi Natalya N Zhou Enhua H EH Lenormand Guillaume G Krishnan Ramaswamy R Weihs Daphne D Butler James P JP Weitz David A DA Fredberg Jeffrey J JJ Kimmel Eitan E

Soft matter 20120201 8

Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10-5) at ultrasonic frequencies (106 Hz), but are closely analogous to those caused by relatively large strains (10-1) at physiological frequencies (100< ...[more]

PMID: 23646063

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