Ontology highlight
ABSTRACT:
SUBMITTER: Sabbaghian N
PROVIDER: S-EPMC3642033 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Sabbaghian Nelly N Bahubeshi Amin A Shuen Andrew Y AY Kanetsky Peter A PA Tischkowitz Marc D MD Nathanson Katherine L KL Foulkes William D WD
BMC research notes 20130401
<h4>Background</h4>The RNase III enzyme DICER1 plays a central role in maturation of microRNAs. Identification of neoplasia-associated germ-line and somatic mutations in DICER1 indicates that mis-expression of miRNAs in cancer may result from defects in their processing. As part of a recent study of DICER1 RNase III domains in 96 testicular germ cell tumors, a single RNase IIIb domain mutation was identified in a seminoma. To further explore the importance of DICER1 mutations in the etiology of ...[more]