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Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.


ABSTRACT: Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y. In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR.

SUBMITTER: Bratty MA 

PROVIDER: S-EPMC3642158 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.

Bratty Mohammed Al MA   Chintapalli Venkateswara R VR   Dow Julian A T JA   Zhang Tong T   Watson David G DG  

FEBS open bio 20120726


Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine bei  ...[more]

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