Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.
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ABSTRACT:
SUBMITTER: Bratty MA
PROVIDER: S-EPMC3642158 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism.
Bratty Mohammed Al MA Chintapalli Venkateswara R VR Dow Julian A T JA Zhang Tong T Watson David G DG
FEBS open bio 20120726
Yellow (y) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow (y) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine bei ...[more]
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