Ontology highlight
ABSTRACT:
SUBMITTER: Trifilieff P
PROVIDER: S-EPMC3642203 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Trifilieff Pierre P Rives Marie-Laure ML Urizar Eneko E Piskorowski Rebecca A RA Vishwasrao Harshad D HD Castrillon John J Schmauss Claudia C Slättman Maria M Gullberg Mats M Javitch Jonathan A JA
BioTechniques 20110801 2
The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been demonstrated in heterologous systems using a variety of biochemical and biophysical assays. While these interactions are the subject of intense research because of their potential role in modulating signaling and altering pharmacology, evidence for the existence of receptor interactions in vivo is still elusive because of a lack of appropriate methods to detect them. Here, we adapted and optimized a proximity lig ...[more]