Ontology highlight
ABSTRACT:
SUBMITTER: Hom K
PROVIDER: S-EPMC3643010 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20130301 5
Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing iron is the oxidative cleavage of heme by HemO. A recent computer aided drug design (CADD) study identified several inhibitors of the bacterial HemOs. Herein we report the near complete HN, N, CO, Cα, and Cβ chemical shift assignment of the P. aeruginosa HemO in the absence and presence of inhibitors (E)-3-(4-(phenylamino)phenylcar ...[more]